Rapid Communication - Benchtop NMR - 31P

One-pot synthesis of (2,4,6-Trimethylbenzoyl)diphenylphosphine oxide from triphenylphosphine oxide
A simple one-pot preparation of (2,4,6-Trimethylbenzoyl)diphenylphosphine oxide* (TPO) by employing the low-cost triphenylphosphine oxide (Ph3PO) as the starting material was described. Reaction with trimethylsilyl chloride (TMSCl) that transforms the intermediate sodium diphenylphosphonite (Ph2PONa) into (trimethylsilyl)oxy)diphenylphosphine (Ph2POTMS) is the key for the high yield of TPO. The reactions of Ph2PONa with other silyl chlorides are discussed.