A novel NMR spectroscopic method for the accurate quantitation of chondroitin sulfate and glucosamines.
This approach stands out by utilizing both low- (80 MHz) and high- (500–600 MHz) field NMR instruments.
Finding: the quantification results from low-field NMR were strikingly similar to those from the more sophisticated high-field NMR devices.
The validation of this method, in terms of accuracy, precision, reproducibility, limit of detection, and recovery, confirms its efficacy for routine quality control of marketed products.
Extending beyond just chondroitin sulfate and glucosamine, this method also successfully analyzes methylsulfonylmethane, potential adulterants like maltodextrin, acetate, and so on.
The choice between low-field and high-field NMR can be guided by the complexity of the sample. While low-field NMR offers a quicker and more cost-effective solution for routine analysis.
