Multicomponent analysis of dietary supplements containing glucosamine and chondroitin: comparative low- and high-field NMR spectroscopic study

A novel NMR spectroscopic method for the accurate quantitation of chondroitin sulfate and glucosamines.
This approach stands out by utilizing both low- (80 MHz) and high- (500–600 MHz) field NMR instruments.
:bar_chart: Finding: the quantification results from low-field NMR were strikingly similar to those from the more sophisticated high-field NMR devices.
:white_check_mark: The validation of this method, in terms of accuracy, precision, reproducibility, limit of detection, and recovery, confirms its efficacy for routine quality control of marketed products.
:globe_with_meridians: Extending beyond just chondroitin sulfate and glucosamine, this method also successfully analyzes methylsulfonylmethane, potential adulterants like maltodextrin, acetate, and so on.
:mag: The choice between low-field and high-field NMR can be guided by the complexity of the sample. While low-field NMR offers a quicker and more cost-effective solution for routine analysis.